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Nikel, P. I., Fuhrer, T., Chavarría, M., Sánchez-Pascuala, A., Sauer, U., and de Lorenzo, V. (2021) Reconfiguration of metabolic fluxes in Pseudomonas putida as a response to sub-lethal oxidative stress. The ISME Journal, DOI: https://doi.org/10.1038/s41396-020-00884-9

This article describes how the carbon fluxes in central metabolism undergo a deep reorganization when the cells are exposed to oxidative insults—similar to the conditions that P. putida encounters in its typical niches. This reconfiguration results in a significant increase in the fluxes that generate NADPH, the metabolic currency key to counteract reactive oxidative species.

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